Designer non-toxic derivatives dodge resistance
نویسندگان
چکیده
منابع مشابه
Non-toxic antimicrobials that evade drug resistance
Drugs that act more promiscuously provide fewer routes for the emergence of resistant mutants. This benefit, however, often comes at the cost of serious off-target and dose-limiting toxicities. The classic example is the antifungal amphotericin B (AmB), which has evaded resistance for more than half a century. We report markedly less toxic amphotericins that nevertheless evade resistance. They ...
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ژورنال
عنوان ژورنال: Nature Reviews Drug Discovery
سال: 2015
ISSN: 1474-1776,1474-1784
DOI: 10.1038/nrd4691